St. Charles Parish officials have ordered evacuation for all 53,000 residents as Tropical Storm Isaac's path moves west.
Parish spokeswoman Renee Simpson says the order was made Sunday evening because conditions are expected to worsen. It's the largest evacuation so far in southeast Louisiana, where 15 parishes are under a hurricane warning.
Administration Commissioner Paul Rainwater says state offices in all 15 affected parishes will be closed Monday.
Earlier Sunday, Grand Isle Mayor ordered evacuation of the state's only occupied barrier island, with tourists to leave Sunday and residents at 9 a.m. Monday.
That's when Lafitte Mayor Tim Kerner called a voluntary evacuation for Lafitte, Crown Point, and Barataria.
Lafourche Parish public schools have joined those closed through Wednesday.
Isaac is expected to make landfall late Tuesday or early Wednesday.