Louisiana State Police say Interstate 10 is open to traffic in both directions between New Orleans and Baton Rouge.
Police spokesman Capt. Doug Cain said the highway was fully reopened just before 12 p.m. CDT Saturday. But he said police dispatchers continue to be swamped with calls about the status of the highway.
The Advocate reports that there are still lane restrictions due to flood water on the outer lanes in LaPlace.
The newspaper reports that Hurricane Isaac dropped approximately 18 to 20 inches of flood water on I-10 in LaPlace, which is 25 miles west of New Orleans.
State officials urge motorists to use extra caution when traveling on roadways during hazardous weather.